NDM resistance is an important antimicrobial resistance mechanism among Gram-negative bacteria. New Delhi metallo-beta-lactamase (NDM) can hydrolyze many beta-lactam antibiotics, making infections caused by NDM-producing organisms challenging to manage. The relationship between Meblanios and NDM resistance is relevant...
Aztreonam avibactam resistance is an emerging microbiological concern as this combination is increasingly studied and used against difficult-to-treat Gram-negative bacteria. Aztreonam-avibactam has a complementary mechanism: aztreonam remains stable against many metallo-beta-lactamases (MBLs), while avibactam inhibits several co-produced serine...
Antimicrobial resistance has made some Gram-negative bacterial infections increasingly difficult to treat. Resistance mechanisms such as extended-spectrum beta-lactamases, AmpC enzymes and metallo-beta-lactamases can reduce the activity of commonly used beta-lactam antibiotics. Meblanios uses are therefore relevant to the...
Metallo-beta-lactamases (MBLs) are important mechanisms of antimicrobial resistance in Gram-negative bacteria. Enzymes such as NDM, VIM and IMP can reduce the activity of many beta-lactam antibiotics and create challenging treatment situations. Meblanios MBL resistance is therefore an important...
Meblanios is an Aztreonam and Avibactam injection containing Aztreonam 1500 mg and Avibactam 500 mg. Developed by AIONIOS Pharma, Meblanios is a combination product relevant to the management of selected difficult-to-treat Gram-negative bacterial infections and antimicrobial resistance. Meblanios...
