Aztreonam-avibactam renal dosing is based on estimated creatinine clearance (CrCl). As renal function declines, the loading dose, maintenance dose, and dosing interval may need to change. Current U.S. prescribing information uses Cockcroft-Gault estimated CrCl to determine the renal dosing category. European product information also uses Cockcroft-Gault for its renal dosing recommendations. Because the U.S. and...Read More