Antimicrobial resistance has made some Gram-negative bacterial infections increasingly difficult to treat. Resistance mechanisms such as extended-spectrum beta-lactamases, AmpC enzymes and metallo-beta-lactamases can reduce the activity of commonly used beta-lactam antibiotics. Meblanios uses are therefore relevant to the broader discussion of Aztreonam and Avibactam combinations and their role in managing selected difficult-to-treat Gram-negative bacterial infections....Read More