Aztreonam avibactam resistance is an emerging microbiological concern as this combination is increasingly studied and used against difficult-to-treat Gram-negative bacteria. Aztreonam-avibactam has a complementary mechanism: aztreonam remains stable against many metallo-beta-lactamases (MBLs), while avibactam inhibits several co-produced serine beta-lactamases. However, this mechanism does not eliminate the possibility of resistance. Recent studies have identified alterations involving...Read More