The aztreonam avibactam mechanism of action involves two complementary roles: aztreonam inhibits bacterial cell-wall synthesis, while avibactam inhibits certain beta-lactamase enzymes that could otherwise destroy aztreonam. This combination is particularly relevant to research on antimicrobial resistance caused by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. Understanding how these two agents work together helps explain the scientific rationale behind...Read More